REFERENCER

Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis

  • Yan Tian, Yafang Zhang, Yu Wang, Yunxi Chen, Weiping Fan, Jianjun Zhou, Jing Qiao, Youzhen Wei
  • Front Physiol. 2021 Dec 20:12:789507.

Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial

  • Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N.
  • Sci Rep. 2020 Jul 22;10(1):12130.
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
  • Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, et al.
  • Nat Med. 2007 Jun;13(6):688-94.
    Molecular hydrogen: a preventive and therapeutic medical gas for various diseases
      • Ohta S.
      • Oncotarget. 2017 Sep 21;8(60):102653-102673.
      Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life
      • Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N.
      • Med Gas Res. 2018 Jan 22;7(4):247-255.

      Effects of hydrogen-rich water on prolonged intermittent exercise

      • Aoki K, Nakao A, Adachi T, Matsui Y, Miyakawa S.
      • J Sports Med Phys Fitness. 2018 May;58(5):612-621.

      The On/Off History of Hydrogen in Medicine: Will the Interest Persist This Time Around?

      • Tyler W. LeBaron, Kini Ohno and John T. Hancock
      • Oxygen 2023, 3(1), 143-162;

      Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

      • Ohta
      • Biochim Biophys Acta. 2012 May;1820(5):586-94.
      Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles.
      • Ichihara, M., et al.
      • Med Gas Res. 2015 Oct 19:5:12.
      Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
      • Ohta, S.
      • Pharmacol Ther. 2014 Oct;144(1):1-11.

      Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases

      • Ohno, K., M. Ito, and M. Ichihara.
      • Oxid Med Cell Longev. 2012:2012:353152.
      Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators
      • Iuchi, K., et al.
      • Sci Rep. 2016 Jan 7:6:18971.

      Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders

      • Chongyun Wu, Peibin Zou, Shu Feng, Ling Zhu, Fanghui Li, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
      • Mol Neurobiol. 2023 Apr;60(4):1749-1765.

      Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes

      • Aoki, K., et al.,
      • Med Gas Res. 2012 Jul 12:2:12.

      Hydrogen Therapy may be a Novel and Effective Treatment for COPD

      • Shu-Lin Liu, Kan Liu, Qiang Sun, Wen-Wu Liu, Heng-Yi and Xue-Jun Sun.
      • Front Pharmacol. 2011 Apr 12:2:19.
      Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases
      • Toru Ishibashi, Miki Ichikawa, Bunpei Sato, Shinji Shibata, Yuichi Hara, Yuji Naritomi, Ken Okazaki, Yasuharu Nakashima, Yukihide Iwamoto, Samon Koyanagi, Hiroshi Hara, Tetsuhiko Nagao
      • Mol Med Rep. 2015 Aug;12(2):2757-64.

      Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

      • Zhiling Fu, Jin Zhang, Yan Zhang
      • Oxid Med Cell Longev. 2022 Mar 18:2022:2249749.

      Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes

      • Hennie Marie Johnsen, Marianne Hiorth, Jo Klaveness
      • Molecules. 2023 Nov 26;28(23):7785.
      Molecular hydrogen therapy for neurological diseases: a review of current evidence
      • Dinesh Ramanathan, Lei Huang, Taylor Wilson, Warren Boling
      • Med Gas Res. 2023 Jul-Sep;13(3):94-98.
      Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives
      • Duried Alwazeer, Franky Fuh-Ching Liu, Xiao Yu Wu, Tyler W LeBaron
      • Oxid Med Cell Longev. 2021 Oct 4:2021:5513868

      Neuroprotective Effects of Molecular Hydrogen: A Critical Review

      • Wei Chen, Han-Ting Zhang, Shu-Cun Qin
      • Neurosci Bull. 2021 Mar;37(3):389-404.
      Hydrogen applications: advances in the field of medical therapy
      • Tao Yuan , Jian-Ning Zhao, Ni-Rong Bao
      • Med Gas Res. 2023 Jul-Sep;13(3):99-107.

      Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases

      • Haru Yamamoto, Yusuke Ichikawa, Shin-Ichi Hirano, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
      • Int J Mol Sci. 2021 Jul 5;22(13):7211

      Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty

      • Johny Bajgai, Kyu-Jae Lee, Md Habibur Rahman, Ailyn Fadriquela, Cheol-Su Kim
      • Curr Pharm Des. 2021;27(5):737-746.

      Molecular hydrogen is a promising therapeutic agent for pulmonary disease

      • Fu, Z., & Zhang, J
      • J Zhejiang Univ Sci B, 23(2), 102-122.

       Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis

      • Jingxi Zhang, Xiumin Feng, Yunxin Fan, Guanglin Zhu, Chong Bai
      • Inflamm Res. 2021 May;70(5):569-579.

      Effect of hydrogen/oxygen therapy for ordinary COVID-19 patients: a propensity-score matched case-control study

      • Yingying Zeng, Weijie Guan, Kai Wang, Zhijun Jie, Xu Zou, Xiaoping Tan, Xinyu Li, Xiaohua Chen, Xiaoting Ren, Junhong Jiang, Zeguang Zheng, Jindong Shi, Nanshan Zhong
      • BMC Infect Dis. 2023 Jun 29;23(1):440.

      Molecular hydrogen (H2 ) as a potential treatment for acute and chronic fatigue

      • Kurt Lucas, Moritz Rosch, Peter Langguth
      • Arch Pharm (Weinheim). 2021 Apr;354(4):e2000378.

      Trend of research on the medical use of molecular hydrogen: a bibliometric analysis

      • He Li, Hong-Yu Ma, Wei-Long Hua, Yong-Xin Zhang, Lei Zhang, Peng-Fei Xing, Peng-Fei Yang, Jian-Min Liu
      • Med Gas Res. 2023 Oct-Dec;13(4):212-218.

      The Potential of Hydrogen for Improving Mental Disorders

      • Yasushi Satoh
      • Curr Pharm Des. 2021;27(5):695-702.

      Hydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19: A retrospective study of medical records

      • Peng Luo, Yuanfang Ding, Yuan He, Dafeng Chen, Qing He, Zufeng Huang, Shian Huang, Wei Lei
      • Medicine (Baltimore). 2022 Mar 4;101(9):e27759.

      Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

      • Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, Petr Konečný, Iva Klimešová, Dalibor Pastucha
      • Int J Environ Res Public Health. 2022 Feb 10;19(4):1992.

      Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial

      • Ze-Guang Zheng, Wu-Zhuang Sun, Jie-Ying Hu, Zhi-Jun Jie, Jin-Fu Xu, Jie Cao, Yuan-Lin Song, Chang-Hui Wang, Jing Wang, Hui Zhao, Zhong-Liang Guo, Nan-Shan Zhong
      • Respir Res. 2021 May 13;22(1):149.

      Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress

      • Shin-Ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Haru Yamamoto, Yoshiyasu Takefuji, Fumitake Satoh
      • Int J Mol Sci. 2021 Mar 4;22(5):2549

      Hydrogen: A Novel Option in Human Disease Treatment

      • Mengling Yang, Yinmiao Dong, Qingnan He, Ping Zhu, Quan Zhuang, Jie Shen, Xueyan Zhang, Mingyi Zhao
      • Oxid Med Cell Longev. 2020 Sep 5:2020:8384742.

      Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes

      • Tyler W LeBaron, Ismail Laher, Branislav Kura, Jan Slezak
      • Can J Physiol Pharmacol. 2019 Sep;97(9):797-807.

      Conventional drug acts as a "rifle gun" while hydrogen as a "machine gun"

      • Shin-Ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
      • Med Gas Res. 2023 Apr-Jun;13(2):89-91.

      Hydrogen as a Potential Therapeutic in Obesity: Targeting the Brain

      • Sergej M Ostojic
      • Trends Endocrinol Metab. 2021 Apr;32(4):191-193.

       Hydrogen Gas in Cancer Treatment

      • Sai Li, Rongrong Liao, Xiaoyan Sheng, Xiaojun Luo, Xin Zhang, Xiaomin Wen, Jin Zhou, Kang Peng
      • Front Oncol. 2019 Aug 6:9:696.